The ASPR Next BAA aims to accelerate the research, development, and availability of transformative products and technologies to protect Americans from natural and intentional health security threats by soliciting revolutionary innovations in health security. Areas of interest include: priority medicines on demand, dialysis care in disaster settings, medical countermeasure deployment and dispensing, real-time healthcare system capacity reporting, disaster response and recovery intelligence, advanced medical interventions, telehealth applications for response and recovery, and health security innovation. All proposals should have the potential to radically change established practice, lead to extraordinary outcomes, or create entirely new fields and commercial market disruptions with wide-ranging impact that will protect Americans from 21st century health threats.